抗原扫描数据库(AntigenScan)

AntigenScan是抗原筛选鉴定数据库,通过序列比对方法,发现刺激T细胞免疫反应的蛋白片段。更重要的是:Angtigen还能提供序列的Pubmed文献来源。

在免疫研究领域,筛选蛋白中具有T细胞激活效应的片段,是一件工作量巨大的任务。

序列比对数据库Blast数据库用于序列比对和搜索,但无法分析出待查询的序列出现在什么论文里。

如果能通过信息比对方法,筛选出经实验验证过的肽段,而后快速进入后续T细胞激活研究阶段,则能达到事半功倍的效果。

AntigenScan数据库就是用于实现该目标,无论您的序列来自于基因测序还是蛋白组学检测,当您期望筛选免疫激活相关抗原肽时,您可以将序列片段提交给本数据库,我们通过数据库序列比对的方法,判断出该蛋白序列是否具有免疫原性的研究证据。

AntigenScan的使用特点

特点1:用户提交序列,可以分析出序列对应的论文,相似序列在抗原识别和T细胞激活领域的相关论文、验证方法。AntigenScan数据量来源于2141篇研究论文,通过文本挖掘、蛋白组质谱序列分析、TCR序列分析等技术,获得了113万条蛋白肽段序列。

特点2:蛋白片段免疫原性经过42种实验方法验证,其免疫原性,已证实可被抗原呈递细胞所呈递,从而帮助研究者节约免疫原筛选的成本和时间。

特点3:抗原结合的MHC种类共515种,涉及所有中国人HLA-I型和II型高频分型。涉及66种小鼠MHC,可供小鼠模型研究使用。研究者可直接使用这些MHC和抗原肽,合成pMHC多聚体,用于捕获抗原特异性T细胞。

特点4:所有抗原肽共涉及9万种蛋白,物种来自于256种病毒、119种细菌、89种人体寄生虫、22种植物,以及人(突变蛋白)、小鼠(突变蛋白),可供自身免疫、过敏源免疫、肿瘤免疫、感染免疫领域的研究发现抗原特异性T细胞。

AntigenScan数据库收录验证实验的类型

  • T细胞表位识别
  • MHC抗体捕获后多肽质谱
  • pMHC多聚体捕获T细胞的流式检测实验
  • pMHC与TCR结合实验
  • 多肽与MHC蛋白、多肽MHC蛋白与TCR复合物共结晶实验
  • 多肽刺激T细胞实验
  • 多肽与MHC结合实验
  • 多肽噬菌体表面展示

AntigenScan的数据提交要求和结果使用建议

  • 提交氨基酸序列最优,也可提交核酸编码区序列,AntigenScan数据库将自动翻译为氨基酸序列。建议用户提供已核实无终止密码子的编码区核酸序列;
  • 多条序列同时分析时,将所有序列合并为一个文件提交,序列名称须具有区分不同序列的能力。

使用AntigenScan分析后,客户后续可进行如下工作:

  • 抗原特异性T细胞的检测与筛选:通过多肽和MHC信息合成pMHC多聚体,用于靶向捕获抗原特异性T细胞。
  • 刺激T细胞的抗原选择:获得抗原蛋白信息,合成抗原并验证方法刺激T细胞刺激使用。

案例1:HBV S抗原蛋白的免疫原性片段筛选

输入序列

>sp|P03138-3|HBSAG_HBVD3 Isoform S of Large envelope protein OS=Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) OX=490133 GN=S

MENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI

输出结果

PubMedMethod/TechniqueantigenhlaNamebitevaluepeptideQuery SequenceTarget Taxonomy
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-A*02:0146.20982.26239E-7NCTCIPIPSSWAFGKFLWEWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*01:0146.20982.26239E-7NCTCIPIPSSWAFGKFLWEWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB5*01:0146.20982.26239E-7NCTCIPIPSSWAFGKFLWEWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*07:0146.20982.26239E-7NCTCIPIPSSWAFGKFLWEWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-A*02:0143.51342.16239E-6QNSQSPTSNHSPTSCPPTCPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*01:0143.51342.16239E-6QNSQSPTSNHSPTSCPPTCPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB5*01:0143.51342.16239E-6QNSQSPTSNHSPTSCPPTCPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*07:0143.51342.16239E-6QNSQSPTSNHSPTSCPPTCPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-A*02:0142.7434.66605E-6SLDSWWTSLNFLGGTTVCLGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*01:0142.7434.66605E-6SLDSWWTSLNFLGGTTVCLGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB5*01:0142.7434.66605E-6SLDSWWTSLNFLGGTTVCLGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*07:0142.7434.66605E-6SLDSWWTSLNFLGGTTVCLGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-A*02:0142.7435.25941E-6LSPTVWLSVIWMMWYWGPSLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB5*01:0142.7435.25941E-6LSPTVWLSVIWMMWYWGPSLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB1*07:0142.7435.25941E-6LSPTVWLSVIWMMWYWGPSLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB1*01:0142.7435.25941E-6LSPTVWLSVIWMMWYWGPSLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-A*02:0142.35786.88407E-6ASARFSWLSLLVPFVQWFVGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB1*01:0142.35786.88407E-6ASARFSWLSLLVPFVQWFVGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB5*01:0142.35786.88407E-6ASARFSWLSLLVPFVQWFVGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB1*07:0142.35786.88407E-6ASARFSWLSLLVPFVQWFVGsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
9366419cellular MHC/competitive/fluorescencesurface antigenHLA-DPA1*01:03/DPB1*02:0141.97268.9195E-6VLQAGFFLLTRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
9366419cellular MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0141.97268.9195E-6VLQAGFFLLTRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
16951350purified MHC/competitive/fluorescenceLarge envelope proteinHLA-DPA1*01:03/DPB1*02:0141.20221.72006E-5VLQAGFFLITRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
16951350purified MHC/competitive/fluorescenceLarge envelope proteinHLA-DPA1*01:03/DPB1*04:0141.20221.72006E-5VLQAGFFLITRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
16951350purified MHC/competitive/fluorescenceLarge envelope proteinHLA-DRA*01:01/DRB1*15:0141.20221.72006E-5VLQAGFFLITRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-A*02:0140.43182.66318E-5PLLVLQAGFFLLTRILTIPQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB1*01:0140.43182.66318E-5PLLVLQAGFFLLTRILTIPQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB5*01:0140.43182.66318E-5PLLVLQAGFFLLTRILTIPQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionenvelope proteinHLA-DRB1*07:0140.43182.66318E-5PLLVLQAGFFLLTRILTIPQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-A*02:0139.66146.25345E-5GMLPVCPLIPGSSTTSTGPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*01:0139.66146.25345E-5GMLPVCPLIPGSSTTSTGPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB5*01:0139.66146.25345E-5GMLPVCPLIPGSSTTSTGPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
1658152cellular MHC/T cell inhibitionpreS1/preS2/S envelopeHLA-DRB1*07:0139.66146.25345E-5GMLPVCPLIPGSSTTSTGPsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
9831134purified MHC/direct/fluorescenceMajor surface antigen precursorHLA-DRB1*04:0138.8910.000102882QAGFFLLTRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
9831134purified MHC/direct/fluorescenceMajor surface antigen precursorHLA-DRB1*04:0438.8910.000102882QAGFFLLTRILTIPQSLDsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0135.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0135.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0135.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0135.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0135.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0135.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0235.0390.00234918PICPGYRWMCLRRFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0134.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0134.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0134.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0134.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0134.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0134.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0234.26860.00514941YRWMCLRRFIIFLFIsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0133.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0133.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0133.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0133.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0133.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0133.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0233.88340.00740069TIPQSLDSWWTSLNFsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0133.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0133.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0133.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0133.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0133.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0133.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0233.49820.0083242VPFVQWFVGLSPTVWsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
23280567purified MHCsurface antigenHLA-B*58:0133.49820.00874218SVIWMMWYWGPSLYNsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0132.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0132.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0132.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0132.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0132.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0132.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0232.72780.0168511ENITSGFLGPLLVLQsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*03:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*03:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*04:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*04:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*04:0532.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*04:0532.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*07:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*07:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*08:0232.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*08:0232.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*09:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*09:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*11:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*11:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*12:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*12:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*13:0232.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*13:0232.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*15:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB1*15:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB3*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB3*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB4*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB4*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15494540purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB5*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
17942551purified MHC/competitive/radioactivityLarge envelope proteinHLA-DRB5*01:0132.34260.0211068LVPFVQWFVGLSPTVsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0132.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0132.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0132.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0132.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0132.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0132.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0232.34260.0249283WLSLLVPFVQWFVGLsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*01:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*03:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*07:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*08:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*11:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*15:0131.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15807858purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0231.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
15915462purified MHC/competitive/fluorescencesurface antigenHLA-DRB1*13:0231.57220.0484932GMLPVCPLIPGSTTTsp|P03138-3|HBSAG_HBVD3_Isoform_S_of_Large_envelope_protein_OS=Hepatitis_B_virus_genotype_D_subtype_ayw_(isolate_France/Tiollais/1979)_OX=490133_GN=SHepatitis B virus subtype adw
  • PubMed:Pubmed文献编号,在Pubmed网站中可精确查找相应文献
  • Method/Technique:抗原验证实验类型
  • antigen:查询到的抗原名称
  • hlaName:与抗原片段结合的MHC亚型
  • bit:查询序列与数据库存储序列的匹配分值
  • evalue:查询序列与数据库存储序列的匹配显著性水平,evalue<0.05
  • peptide:查询序列与数据库存储序列匹配的抗原肽
  • Query Sequence:查询序列
  • Target Taxonomy:匹配的数据库存储序列的物种

案例2:TP53突变蛋白的免疫原性片段筛选

输入序列

第一条序列为tp53蛋白175位、248位、273位突变后的序列,三个突变位点来自于TCGA数据库

第二条序列为tp53蛋白isoform1野生型序列,作为对照序列。

>mute_175_248_273sp|P04637|P53_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRHCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNQRPILTIITLEDSSGNLLGRNSFEVHVCACPGRDRRTEEENLRKKEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKGQSTSRHKKLMFKTEGPDSD

>sp|P04637|P53_HUMAN Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

输出结果

PubMedMethod/TechniqueantigenhlaNamebitevaluePeptideQuery Sequence
18056201purified MHC/competitive/fluorescenceCellular tumor antigen p53HLA-DQA1*03:01/DQB1*03:0133.1130.0216838NTFRHSVVVPYEPPmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
18056201purified MHC/competitive/fluorescenceCellular tumor antigen p53HLA-DQA1*03:01/DQB1*03:0132.72780.0279567NSFEVRVCACPGRDmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
18056201purified MHC/competitive/fluorescenceCellular tumor antigen p53HLA-DQA1*03:01/DQB1*03:0130.80180.147249MNRRPILTIITLEDmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
31848261cellular MHC/mass spectrometryCellular tumor antigen p53HLA-A*33:0130.80180.157476EYFTLQIRGRERmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
31844290mass spectrometryCellular tumor antigen p53HLA-A*33:0130.80180.157476EYFTLQIRGRERmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
34561969mass spectrometryCellular tumor antigen p53HLA-A*33:0130.80180.157476EYFTLQIRGRERmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
31848261cellular MHC/mass spectrometryCellular tumor antigen p53HLA-A*33:0330.80180.157476EYFTLQIRGRERmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
31844290mass spectrometryCellular tumor antigen p53HLA-A*33:0330.80180.157476EYFTLQIRGRERmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
34561969mass spectrometryCellular tumor antigen p53HLA-A*33:0330.80180.157476EYFTLQIRGRERmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
32161166cellular MHC/mass spectrometryp53 transformation suppressor, partial [Homo sapiens]HLA-B*51:0130.03140.276863SDSDGLAPPQHLImute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
18056201purified MHC/competitive/fluorescenceHLA-DQA1*03:01/DQB1*03:0129.64620.344616NTFRHSVVVPCEPPmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
18056201purified MHC/competitive/fluorescenceHLA-DQA1*03:01/DQB1*03:0129.2610.489935NSFEERVCACPGRDmute_175_248_273sp|P04637|P53_HUMAN_Cellular_tumor_antigen_p53_OS=Homo_sapiens_OX=9606_GN=TP53_PE=1_SV=4
  • PubMed:Pubmed文献编号,在Pubmed网站中可精确查找相应文献
  • Method/Technique:抗原验证实验类型
  • antigen:查询到的抗原名称
  • hlaName:与抗原片段结合的MHC亚型
  • bit:查询序列与数据库存储序列的匹配分值
  • evalue:查询序列与数据库存储序列的匹配显著性水平,evalue<0.05
  • peptide:查询序列与数据库存储序列匹配的抗原肽
  • Query Sequence:查询序列
  • Target Taxonomy:匹配的数据库存储序列的物种

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